Date: 9/28/2009
TUMSPR: TA is uncommon before the 10th year of life but it should be considered in patients presenting with hypertension and systemic symptoms such as fever, limb pain and pulseless limb. [H]
TUMES REPORT:based on a report by the public relations of TUMS Children Medical Center, Dr. Mohammad Hassan Moradinejad has published an article in Iran Journal of Pediatrics on three cases with Takayasu arteritis.
Takayasu arteritis (TA) or giant cell vasculitis is the third common vasculitis after Henoch-Schoenline purpura and Kawasaki disease in children. This vasculitis usually affects large vessels and is more common in females during the childhood. The article presents three Iranian children (two males and a female) with TA. Mean age of the cases on admission has been 10 years. The patients most commonly presented with episodes of systemic symptoms including fever, headache, increased arterial blood pressure in one limb and convulsion. Other related symptoms were myalgia, limb, chest and abdominal pain. Supra-sternal, and abdominal bruit were noted in all patients.
Angiography revealed stenosis of the left subclavian artery and common carotid artery in one patient, generalized aortitis in another and stenotic right renal artery in the third patient. One boy was diagnosed with systemic onset of idiopathic juvenile arthritis. Follow-ups ranged from 2 to 7 years from the diagnoses. All patients were treated with prednisone, azathioprine, aspirin, and antihypertensive drugs. Each patient received either methotrexate, or hydroxychloroquine or mycofenolate mofetil.
Although TA is uncommon before the 10th year of life, it should be considered in patients presenting with hypertension and systemic symptoms such as fever, limb pain and pulseless limb.
http://publicrelations.tums.ac.ir/english/news/detail.asp?newsID=13635
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