Date: 7/11/2011
TUMSPR News: Dr. Sanford Martin Dawsey, a senior investigator at the US National Cancer Institute, gave a Lecture entitled “PAH as a universal carcinogen for upper GI tract cancer " at TUMS Digestive Diseases Research Center on July 7th 2011.
Based on the news by the Public Relations of the Digestive Diseases Research Center (DDRC), affiliated to Tehran University of Medical Sciences (TUMS), Dr. Sanford Martin Dawsey, a senior researcher from the US National Cancer Institute, gave a Lecture on “Polycyclic aromatic hydrocarbon (PAH) as a universal carcinogen for upper GI tract cancer" on July 7, 2011. Dr. Malekzadeh, the head of DDRC and the faculty members and the Center's fellows attended the lecture.
Dr. Dawsey summarized the evidence regarding the role of polycyclic aromatic hydrocarbons (PAHs) in esophageal cancer. PAHs are a class of carcinogens which are produced mainly by incomplete fuel combustion. Environmental sources of PAH exposure include cigarette smoke, air pollution, coal and diet. Cross-sectional studies in high-incidence areas of esophageal squamous cell carcinoma (ESCC) in Linxian (China) and Golestan Province (Iran) indicate that the inhabitants of these areas are highly exposed to PAHs.
While tobacco smoking is a known risk factor for ESCC and a major source of exposure to PAHs, high exposure levels to PAHs in Golestan were observed among non-smokers as well as smokers, and only 15% of the variance in PAH levels in urine was explained by known factors, such as age, sex, place of residence (rural vs. urban), and tobacco use.
A recent case-control study in Golestan Province reported higher levels of antibodies against benzo[a]pyrene-diol-epoxide-I-modified guanosine in non-tumoral esophageal biopsies from patients with biopsy-proven ESCC than in biopsies from control subjects, which suggests a causal role for PAHs in esophageal carcinogenesis in the region.
http://publicrelations.tums.ac.ir/english/news/detail.asp?newsID=25844
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